The No. 2 Indiana Hoosiers (11-0) hit the road for a Big Ten battle against the Purdue Boilermakers (2-9) on Friday, November 28, 2025 at Ross-Ade Stadium.

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Indiana vs. Purdue Matchup Info

Game date: Friday, November 28, 2025
Game time: 7:30 p.m. ET
Location: West Lafayette, Indiana
Venue: Ross-Ade Stadium
TV channel: NBC
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Indiana vs. Purdue Odds and Prediction

Spread favorite: Hoosiers (-28.5)
Moneyline: Hoosiers (-7143), Boilermakers (+1810)
Total: 53.5 points
Pick ATS: Indiana (-28.5)
Pick OU: Under (53.5)
Prediction: Indiana 42, Purdue 9

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Indiana vs. Purdue Betting Records and Insights

Indiana has won six games against the spread this season, while failing to cover five times.
Purdue has compiled a 5-6-0 ATS record so far this year.
The Hoosiers have been favored by 28.5 points or more three times this season, and covered the spread in two of those contests.
The Boilermakers have won their only game this season when playing as at least 28.5-point underdogs.
In Indiana's 11 games this season, the combined scoring has gone over the point total seven times.
Purdue and its opponent have combined to hit the over three out of 11 times this season.

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