Anthony Castonzo has never made a Pro Bowl, but he's arguably the most important Colt not named Andrew Luck. He's started 93 of their last 96 games and has been the Colts' lone stable force on an ever-changing offensive line unit.
Castonzo has been dealing with a hamstring issue for weeks (months?) and it could keep him out of the opener. The good news? He was on the practice field today:
It would be huge if Castonzo could go against the Bengals, because Indy has zero tackle depth. The two players behind him are J'Marcus Webb, who they got off the street a few weeks back, and Le'Raven Clark, who probably should've been cut.
The Colts are already rolling with a backup-caliber player on the other side in Joe Haeg, so you would hate to see average/mediocre bookends protecting Andrew Luck in his first real NFL game in 600+ days.