Notre Dame vs. Louisville Football Prediction & Odds - Sept. 28

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The No. 15 Louisville Cardinals (3-0) visit the No. 16 Notre Dame Fighting Irish (3-1) at Notre Dame Stadium on Saturday, September 28, 2024.

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Notre Dame vs. Louisville Matchup Info

Game date: Saturday, September 28, 2024Game time: 3:30 p.m. ETLocation: South Bend, IndianaVenue: Notre Dame StadiumTV channel: PeacockStop missing games and start streaming college football right now on Fubo.

Notre Dame vs. Louisville Odds and Prediction

  • Spread favorite: Fighting Irish (-6.5)Moneyline: Fighting Irish (-250), Cardinals (+200)Total: 45.5 pointsPick ATS:

Louisville (+6.5)

Pick OU: Over (45.5)

Prediction: Notre Dame 26, Louisville 24Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Notre Dame vs. Louisville Betting Records and Insights

Notre Dame has a record of 2-2-0 against the spread this season.Louisville has covered in each of its two games with a spread this season.The Fighting Irish have covered the spread once this season (1-2 ATS) when playing as at least 6.5-point favorites.Notre Dame games have gone over the point total just once this season.Louisville games have gone over the point total once this year.


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