Ohio St vs. Purdue Football Prediction & Odds - Nov. 8

Penn State v Ohio State

Photo: Jason Mowry / Getty Images Sport / Getty Images

Big Ten opponents match up when the No. 1 Ohio State Buckeyes (8-0) and the Purdue Boilermakers (2-7) square off on Saturday, November 8, 2025 at Ross-Ade Stadium.

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Ohio State vs. Purdue Matchup Info

  • Game date: Saturday, November 8, 2025
  • Game time: 1 p.m. ET
  • Location: West Lafayette, Indiana
  • Venue: Ross-Ade Stadium
  • TV channel: BTN
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Ohio State vs. Purdue Odds and Prediction

  • Spread favorite: Buckeyes (-29.5)
  • Moneyline: Buckeyes (-8333), Boilermakers (+2140)
  • Total: 48.5 points
  • Pick ATS: Ohio State (-29.5)
  • Pick OU: Under (48.5)
  • Prediction: Ohio State 37, Purdue 7

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Ohio State vs. Purdue Betting Records and Insights

  • Ohio State has won seven games against the spread this season, while failing to cover once.
  • Purdue has compiled a 4-5-0 record against the spread this season.
  • The Buckeyes have covered the spread when playing as at least 29.5-point favorites in their only opportunity this season.
  • So far this season, three of Ohio State's eight games have gone over the point total.
  • This season, games featuring Purdue have gone over the point total just twice.

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