The No. 20 USC Trojans (5-1) visit the No. 13 Notre Dame Fighting Irish (4-2) at Notre Dame Stadium on Saturday, October 18, 2025.
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Notre Dame vs. USC Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 7:30 p.m. ET
- Location: South Bend, Indiana
- Venue: Notre Dame Stadium
- TV channel: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Notre Dame vs. USC Odds and Prediction
- Spread favorite: Fighting Irish (-9.5)
- Moneyline: Fighting Irish (-347), Trojans (+276)
- Total: 61.5 points
- Pick ATS: Notre Dame (-9.5)
- Pick OU: Over (61.5)
- Prediction: Notre Dame 40, USC 24
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Notre Dame vs. USC Betting Records and Insights
- Notre Dame has put together a 3-3-0 record against the spread this season.
- USC has covered three times in six chances against the spread this season.
- The Fighting Irish have covered the spread twice this season (2-1 ATS) when playing as at least 9.5-point favorites.
- A total of four out of six Notre Dame games this season have hit the over.
- In 2025, four USC games have gone over the point total.