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Big Ten opponents match up when the No. 3 Indiana Hoosiers (6-0) and the Michigan State Spartans (3-3) square off on Saturday, October 18, 2025 at Memorial Stadium (Bloomington, IN).
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Indiana vs. Michigan State Matchup Info
- Game date: Saturday, October 18, 2025
- Game time: 3:30 p.m. ET
- Location: Bloomington, Indiana
- Venue: Memorial Stadium (Bloomington, IN)
- TV channel: Peacock
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Indiana vs. Michigan State Odds and Prediction
- Spread favorite: Hoosiers (-27.5)
- Moneyline: Hoosiers (-5556), Spartans (+1720)
- Total: 49.5 points
- Pick ATS: Indiana (-27.5)
- Pick OU: Over (49.5)
- Prediction: Indiana 49, Michigan State 7
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Indiana vs. Michigan State Betting Records and Insights
- Indiana has compiled a 4-2-0 ATS record so far this year.
- Michigan State has won two games against the spread this year.
- The Hoosiers have been favored by 27.5 points or more two times this season, and covered the spread in both.
- In Indiana's six games this season, the combined scoring has gone over the point total three times.
- So far this season, four of Michigan State's six games with a set number have hit the over.