The Indianapolis Colts should win their game versus the Arizona Cardinals at 1 p.m. ET on Sunday, Oct. 12, according to our computer projections. If you're seeking more projections on the final score, spread, and point total, we've got you covered below.
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Colts vs. Cardinals Game Info and TV Channel
- When: Sunday, October 12, 2025 at 1 p.m. ET
- Where: Lucas Oil Stadium in Indianapolis, Indiana
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 107.5 The Fan
Colts vs. Cardinals Odds and Betting Info
- Spread favorite: Colts (-9.5)
- Moneyline: Colts (-495), Cardinals (+372)
- Total: 46.5 points
Colts vs. Cardinals Prediction
- Pick ATS: Colts (-9.5)
- Pick OU: Under (46.5)
Prediction:
Colts 31 - Cardinals 14
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Colts vs. Cardinals Betting Insights
- The Colts have put together a 4-1-0 record against the spread this season.
- The Cardinals have a record of 2-3-0 against the spread this year.
- So far this season, two Colts games have gone over the point total.
- Cardinals games have hit the over twice this season.
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