Indiana vs. Iowa Football Prediction & Odds - Sept. 27

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The No. 11 Indiana Hoosiers (4-0) hit the road for a Big Ten showdown against the Iowa Hawkeyes (3-1) on Saturday, September 27, 2025 at Kinnick Stadium.

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Indiana vs. Iowa Matchup Info

  • Game date: Saturday, September 27, 2025
  • Game time: 3:30 p.m. ET
  • Location: Iowa City, Iowa
  • Venue: Kinnick Stadium
  • TV channel: Peacock

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Indiana vs. Iowa Odds and Prediction

  • Spread favorite: Hoosiers (-8.5)
  • Moneyline: Hoosiers (-319), Hawkeyes (+256)
  • Total: 47.5 points
  • Pick ATS: Indiana (-8.5)
  • Pick OU: Over (47.5)
  • Prediction: Indiana 48, Iowa 6

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Indiana vs. Iowa Betting Records and Insights

  • Indiana has covered three times in four chances against the spread this season.
  • Iowa has covered twice in four games with a spread this year.
  • The Hoosiers have covered the spread twice when favored by 8.5 points or more this season (in three opportunities).
  • Indiana and its opponent have combined to go over the point total three out of four times this season.
  • Iowa games have gone over the point total twice this season.

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