The Notre Dame Fighting Irish (11-11, 2-7 ACC) will visit the Louisville Cardinals (15-6, 5-4 ACC) after losing four road games in a row.
Wednesday's matchup between the Cardinals and the Fighting Irish features the Cardinals as colossal 17.5-point favorites. The over/under is 154.5 points for the matchup.
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Louisville vs. Notre Dame Odds and Game Info
- Game day: Wednesday, February 4, 2026
- Game time: 7 p.m. ET
- TV channel: ESPN2
- Location: Louisville, Kentucky
- Arena: KFC Yum! Center
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Louisville vs. Notre Dame Odds and Prediction
- Spread favorite: Louisville (-17.5)
- Moneyline: Louisville (-2381), Notre Dame (+1126)
- Total: 154.5 points
Pick ATS:Notre Dame (+17.5)
- Pick OU: Under (154.5)
- Prediction: Louisville 82, Notre Dame 69
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Louisville vs. Notre Dame Comparison
| Louisville Rank | Louisville Stat | Notre Dame Stat | Notre Dame Rank | |
|---|---|---|---|---|
| 23rd | 86.1 | Points Scored | 74 | 243rd |
| 89th | 70.5 | Points Allowed | 72.2 | 142nd |
| 26th | 17.6 | Assists | 12 | 313th |
| 188th | 11.3 | Turnovers | 10.9 | 149th |
| 119th | 46.3% | Field Goal % | 45% | 197th |
| 33rd | 40.4% | Field Goal % Allowed | 43.2% | 144th |
Louisville Key Players
- The Cardinals scoring leader is Ryan Conwell, who averages 19.1 per contest to go with five rebounds and 2.6 assists.
- Sananda Fru leads Louisville in rebounding, averaging 6.7 per game, while Aly Khalifa leads the team in assists, distributing an average of 2.8 in each contest.
- Conwell leads the Cardinals in three-point shooting, knocking down an average of 3.7 shots per game from beyond the arc.
- Conwell is Louisville's leader in steals, averaging 1.4 steals per game, while Fru leads them in blocks with 1.3 per contest.
Notre Dame Key Players
- Jalen Haralson collects 15.5 points and tacks on 2.6 assists per game, and is at the top of the Fighting Irish's leaderboards for those statistics.
- Carson Towt is at the top of the Notre Dame rebounding leaderboard with 9.5 rebounds per game. Towt also racks up 6.5 points and adds 1.7 assists per game.
- Braeden Shrewsberry averages 2.8 three-pointers per game, the most on the Fighting Irish.
- Notre Dame's leader in steals is Logan Imes (0.7 per game), and its leader in blocks is Brady Koehler (0.6 per game).
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